Mercedes-Benz E450 E-Class exterior | vs. E350

Mercedes E350 vs. E450: The 7 Differences & Which Is Best?

So, you’ve got your eyes set on the Mercedes-Benz E-Class, huh?

A stellar choice, if we may say so!

Now, if you’re like many car enthusiasts, you might be stuck deciding between two models: the E350 and the E450. And we totally get it – the decision isn’t easy!

The main difference between the Mercedes E350 and E450 is that the E350 has a 2.0-liter, 4-cylinder engine, while the E450 has a more powerful 3.0-liter, straight 6-cylinder engine, complemented by a mild electric hybrid system.

But that’s not all! In this article, we will discuss their engines, fuel efficiency, features, and even their price tags.

Let’s get started!

7 Differences between the Mercedes E350 and E450

Let’s look at all the differences between a Mercedes E350 and an E450!

1. Engine

Alright, let’s dive into the heart of any car – the engine!

E350: Starting with the E350, it has a 2.0-liter, 4-cylinder engine. With this setup, you can expect 255 horsepower and 273 lb-ft of torque. And, just to be clear, this one’s running on good old gasoline.

Mercedes E350 E-Class engine
Mercedes-Benz E350 engine

E450: Now, onto the E450. This model steps things up a notch. Under its hood lies a 3.0-liter, straight 6-cylinder engine, which pushes out an impressive 362 horsepower and 369 lb-ft of torque.

Mercedes E450 E-Class engine
Mercedes-Benz E450 engine

What’s noteworthy is that it’s not just a gasoline engine; it’s a combination of gasoline and a mild electric hybrid. This means you’re getting the best of both worlds – smooth power delivery and better efficiency.

Here is an overview of the engines of the E350 and E450 and their performance:

MercedesEnginePower (hp)Torque (lb-ft)0 to 62 mphTop speed
E3502.0-liter four cylinder2552736.2 seconds155 mph (250 km/h)
E4503.0-liter inline six3623695.0 seconds155 mph (250 km/h)

In conclusion, the Mercedes-Benz E450 has a larger and more powerful engine than the E350!

Reader’s tip: Which Mercedes E-Class Engine Is Best In 2024? (+2 To Avoid)

2. Fuel efficiency

Let’s talk about how often you’ll be visiting the gas station.

E350: The Mercedes E350 is a pretty efficient traveler. It offers a combined fuel efficiency of 26 MPG. That means, on average, for every gallon of gasoline you pour in, this car can cruise for 26 miles. Not too shabby, right?

Mercedes E350 E-Class exterior
Mercedes-Benz E350

E450: The Mercedes E450, despite its powerful engine, comes in just a tad lower at 25 combined MPG. While it’s only a mile less than the E350 per gallon, it showcases how combining a larger engine with hybrid technology can still maintain decent fuel efficiency.

In essence, both cars do a great job of balancing power and fuel consumption. However, the fuel efficiency of the E450 is arguably even more impressive. Even though its engine is 50% larger, it still offers roughly the same fuel consumption!

Related article: Which Mercedes E-Class Is The Most Fuel-Efficient? (2024)

3. Fuel tank

This difference is essential for those long road trips or just fewer trips to the pump – the fuel tank capacity!

E350: The Mercedes E350 comes equipped with a 17.4-gallon tank. While it may seem average at first glance, when paired with its commendable MPG, you’ve got a car that can cover quite a distance before needing a refill.

E450: The Mercedes E450 has a larger 21.1-gallon tank. If you assume the E450 will reach its claimed combined fuel consumption, this fuel tank will give you a range of over 500 miles!

Reader’s tip: Mercedes E-Class: Regular Or Premium Gas? (2024 Guidelines)

4. Front-wheel-drive vs. all-wheel-drive

The following difference is about the drive system!

It plays a pivotal role in how a car feels on the road, especially during those twists, turns, and sudden accelerations.

E350: The Mercedes E350 is available as either a rear-wheel drive (RWD) or an all-wheel drive (AWD) car.

E450: In contrast, the Mercedes E450 is always equipped with Mercedes’ 4MATIC system, making it an all-wheel-drive car.

Mercedes E450 E-Class 4MATIC badge

The 4MATIC system helps to improve traction in all kinds of weather conditions. That means you won’t struggle to get off the line, even in wet conditions!

As a result, the E450 4MATIC is the better choice for drivers who use their car in winter conditions and want the best possible performance.

5. Weight

Alright, let’s shift our focus to something that quite literally ‘weighs’ on a vehicle’s performance – the curb weight!

This might not be the first thing you notice when you see a car, but it certainly plays a significant role in how a car feels and behaves on the road.

E350 4MATIC: The E350 4MATIC comes in at a neat 3,924 lbs. It’s not exactly lightweight in the grand scheme of cars, but for a luxury sedan, this is fairly standard.

E450 4MATIC: The E450 4MATIC, however, weighs 4,222 lbs. And there’s a reason for that extra heft. This model houses a larger 6-cylinder engine combined with a mild electric hybrid system. These components, especially the bigger engine, add to the overall weight.

Now, you might wonder, “What does this difference in weight mean for me?”

A heavier car like the E450 typically feels more planted and stable, especially at higher speeds. However, it might be slightly less agile when zipping through tight corners. On the other hand, the lighter E350 might feel a bit more nimble and responsive during city drives or twisty back roads.

Mercedes E350 E-Class interior
Mercedes-Benz E350 interior

In simpler terms, imagine carrying a backpack.

The E350 is like having a bag with just the essentials – moving quickly and changing direction is easier. The E450, with its added weight, is like carrying a backpack with a laptop and a few books – it feels more substantial, but it’s also reassuringly solid.

6. Standard features

Both the E350 and E450 come loaded with impressive tech and luxury features that define the Mercedes-Benz experience.

However, there’s one standout feature on the E450.

The main difference in the standard features of the Mercedes E350 compared to the Mercedes E450 is that the E450 gets the sports brakes system as standard, while they are optional on the E350.

These sports brakes are designed for enhanced stopping power, greater heat dissipation, and improved longevity, especially under spirited driving conditions.

Mercedes E450 E-Class sports brakes

Article tip: 7 Reasons You Should Buy A (Used) Mercedes E-Class In 2024

7. The price tag

Now, let’s address the elephant in the room – the price tag!

The Mercedes E350 comes with an MSRP of about $55,000, while the E450 carries an MSRP of about $63,000. That means the E450 is about $8,000 more expensive than the E350 when you compare the base versions.

To put it in perspective, consider it like choosing between two high-end smartphones. The E350 is that flagship phone that offers everything most people need, while the E450 is like the ‘Pro’ version with a few extra bells and whistles.

What is the best choice? (Mercedes E350 vs. E450)

So, after diving deep into the specs, features, and price tags, you might be scratching your head, wondering, “Which one is right for me?”

Let’s get to the heart of the matter!


Your choice largely depends on what you want in a car. If you desire more pep in your drive and enjoy the feel of a larger engine, the E450 might be your cup of tea.

On the other hand, the E350 offers a blend of performance and efficiency without compromising on luxury. It’s perfect for those who want a refined driving experience but are also mindful of their budget.

Driving conditions

Consider the terrain and climate where you drive most often. If you’re in a region that frequently faces tricky weather conditions, the 4MATIC versions of the E350 and E450 can offer added peace of mind with improved traction.

Economic considerations

While the E450 does come at a premium, remember that it offers a few unique features and technologies that the E350 doesn’t. But then again, if those features aren’t vital to you, why stretch the budget?

Future resale

Both cars, being from the Mercedes-Benz family, will hold their value relatively well. However, the E450, with its hybrid tech and more powerful engine, might be more appealing in the resale market down the line.

In a nutshell, there’s no definitive ‘better’ choice here; both vehicles are stellar. It all boils down to personal taste. Reflect on what you prioritize more: Is it raw power and additional tech or a balanced blend of luxury and value?

Mercedes E450 E-Class exterior rear

Power difference

If you ever want to get the power of the E450 or more in your E350, you can always consider getting a RaceChip.

RaceChip is a company offering Plug & Drive tuning box systems for many car models. They can be installed by yourself without needing any specialist knowledge or tools.

In fact, it will only take 10 to 15 minutes, and when you buy a RaceChip, you’ll receive car model-specific installation instructions!

Using a RaceChip, you can give your Mercedes E350 a performance boost of up to 54 horsepower and 50 lb-ft of torque:

Mercedes E350 chip tuning power increase - RaceChip

And the best thing is, a RaceChip is much more affordable than the upgrade from an E350 to an E450. You can check out RaceChip’s website here!

Related article: Is A Mercedes E-Class Worth It In 2024? (10 Pros & Cons)


To conclude, the Mercedes E350 is the better choice for those looking for a more affordable car. It is cheaper than the E450, yet it still offers many of the same features.

The E450 is a better choice for those who prioritize performance. It has a more powerful engine and better acceleration.

Good luck with your choice!

More E-Class comparisons

Not sure if these Mercedes E-Class models are right for you? Don’t worry, there are more options to choose from:

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